sickle

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Fetal hemoglobin increases safely with increased hydroxyurea in infants with sickle cell anemia

Meghna Dua, MD, Department of Global Pediatric Medicine, St. Jude Children’s Research Hospital, presented data from her team’s findings regarding hydroxyurea dosing in very young children with sickle cell disease (SCA) during the American Society of Hematology (ASH) Annual Meeting and Exposition. With little published research on infants’ tolerance to hydroxyurea dose escalation, Dua and …

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HCP Live

Pyruvate kinase activators may benefit vaso-occlusive crisis in sickle cell disease

A pair of pyruvate kinase (PKA) activators have been linked to increased oxygen affinity and reduced propensity for red blood cell sickling in patients with sickle cell disease in vitro, according to new findings. In data presented at the 2022 Annual Meeting of the American Society of Hematology (ASH) in New Orleans this week, a …

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